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br Conclusions br In summary our study provides proof
2020-03-24
4. Conclusions In summary, our study provides proof-of-concept for 7pep-M-RAP as a novel treatment modality to improve the therapeutic efficacy of chemotherapeutic nanomedicine. 7pep-M-RAP revealed synergistic anti-tumor effect with cytotoxic 7pep-M-PTX on MCF-7 breast cancer. Through ligand‒re
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A MTT analysis of AsPC pLXSN Adh
2020-03-24
A) MTT analysis of AsPC-1 + pLXSN (Adh.) HG-9-91-01 plated with the different NAX compounds. In Panel B, the IC50s are presented graphically. All of the experiments indicated in this figure were performed on the same day. These experiments were repeated 3 times and similar results were obtained.
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b iframe width height src https www youtube com
2020-03-24
r> In this study we investigated the role and the potential of targeting ABC transporters in PDAC therapy. We showe that a member of the ABCC family, ABCC3, is highly expressed in PDAC tumours and that its expression is dependent on mutation of TP53. We also show that ABCC3 is required for LPI-medi
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Sudhir Krishnaa br a National Centre
2020-03-17
Sudhir Krishnaa, a National Centre for Biological Sciences, Tata Institute of Fundamental Research, GKVK-UAS, Bangalore 560065, Karnataka, India b Department of Pathology, Kidwai Cancer Institute, Bangalore, India c The Babraham Institute, Cambridge, UK d School of Biological Sciences, Univers
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br Rosenthal SJ Chang JC Kovtun
2020-03-17
[6] Rosenthal SJ, Chang JC, Kovtun O, McBride JR, Tomlinson ID. Biocompatible quantum dots for biological applications. Chem Biol 2011;18:10–24. [7] Bohara RA, Thorat ND, Pawar SH. Role of functionalization: strategies to explore potential nano-bio applications of magnetic nanoparticles. RSC Ad
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br Conclusions br Metastatic lung cancer is
2020-03-17
7. Conclusions Metastatic lung cancer is a condition with poor prognosis in regards to its high morbidity and mortality. In this study, we aimed to analyze these various management modalities specifically for patients with metastatic lung cancer affecting the spine. Our sys-tematic review on th
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br Gene set analysis br To
2020-03-17
Gene set analysis To quantify the extent to which different groups of genes were enriched in a given metric (e.g., p values from a DE analysis), a gene set analysis (GSA) was performed. This type of analysis was applied in a number of situations throughout the study, and followed the same proce
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br Findings We established a prognostic panel designated as
2019-11-12
Findings: We established a prognostic panel, designated as tumour microenvironment risk score (TMRS), consisting of 100 genes. With specific risk score formulae, the TMRS panel possesses a strong ability to predict relapse-free survival and overall survival through both univariate and multivariate
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br Ethical considerations br Ethical approval was obtained f
2019-11-11
Ethical considerations Ethical approval was obtained from the ethics committees of univer-sity institutions. Table 1 Semi-structured interview guide. No. Questions 1 How is your child's hospitalization affecting you and your family? (Probe for effects on work, finances, and family a
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Filipin III br Background br The large datasets consist of l
2019-10-29
2. Background The large datasets consist of “large p-number of features, n-number of samples, p > n” problem may have the issue of overfitting. A model which is over fitted can cause fluctuations for critical change in the in-formation which can result in errors in the classification accuracy.
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br Fig A Cytotoxicity of GNR and DHHC GNRAH
2019-10-22
Fig. 9. (A) Cytotoxicity of GNR and DHHC-GNRAH after 24 h of incubation in the absence of DOX and NIR irradiation. (B) Viability of MCF-7 Bradykinin (acetate) incubated with different concentrations of free DOX, DHHC-GNRAH, [email protected] and DOX-DHHC-GNRAH for 24 h in the presence and absence
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br The results of elemental analysis
2019-10-18
The results of elemental analysis confirmed that aphaOMe ligand was formed and that there is one chloride, one acetate and one cad-mium ion per ligand molecule. The existence of acetate anion in 1 was confirmed by IR spectroscopy. Two very strong bands, characteristic for bidentate acetate coordin
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br Corresponding authors at No Penglai Road Daliang District
2019-10-15
Corresponding authors at: No. 1, Penglai Road, Daliang District, Shunde, Foshan, Guangdong, PR China. 1 These authors contributed equally to this work. spaces (lymphatic and/or blood vessel) by tumoral cells, i.e. tumor cells spreading through the lymphatic or blood vascular networks [5]. Pe
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br in SCLC progression HDLBP was originally reported
2019-10-15
in SCLC progression. HDLBP was originally reported to be involved in cholesterol-level regulation, but its relationship with cancer has been recently paid attention (e.g. it was found to be overexpressed in liver cancer tissue but downregulated in breast cancer tissue) with unclear mechanism [13,1
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br A research was conducted by Garc a
2019-10-14
A research was conducted by García, Sánchez, Cleofas-Sánchez, Ochoa-Domínguez, and López-Orozco (2017) to analyze the effect of high-dimensional data on the classification of gene GSK126 datasets. Gain ratio and ReliefF were used as gene ranking meth-ods with six classifiers on four biomedical da