• The mitochondrial haplotype constitutes the genetic backgrou

  2019-07-30

  

  The mitochondrial haplotype constitutes the genetic background for host cells invaded by HBV. A comprehensive study on peripheral blood, tumor and/or adjacent non-tumor tissue from 49 HBV-HCC patients and 38 normal people revealed that people with mtDNA haplogroup M may have increased likelihood of

• Many receptor tyrosine kinases are expressed in activated HS

  2019-07-30

  

  Many receptor tyrosine kinases are expressed in activated HSCs and are associated with the development of liver fibrosis. These include platelet-derived growth factor receptor (PDGFR) [10], vascular endothelial growth factor receptor (VEGFR) [11], and epidermal growth factor receptor (EGFR) [12]. On

• br Materials and methods br Results

  2019-07-24

  

  Materials and methods Results Discussion In this study, we show that adaptive modifications of Ca2+ cycling through the hypertrophic response to chronic high blood pressure overload play a critical role during early development of MitoPY1 failure with nearly-normal ejection fraction (HFpEF

• br Materials and methods br

  2019-07-24

  

  Materials and methods Results Discussion Here, we described a mouse model in which paternal exposure to hyperglycemia leads to metabolic derangement and accumulation of fatty Etoposide in the adult offspring liver. Deregulation of genes related to hepatic lipid metabolism can be explained,

• br Transparency document br Introduction Inflammation

  2019-07-11

  

  Transparency document Introduction Inflammation is a physiological response of the immune system to defend the body against injury or infection [1,2]. Generally, inflammation is considered as a protective response to injury or infection, due to its functions in eliminating pathogenic stimuli a

• br Author contributions br Transparency document br Introduc

  2019-07-08

  

  Author contributions Transparency document Introduction Sepsis, characterized by dysregulation of systemic immunity and subsequent multiple organ failure, is the leading cause of death among hospitalized patients [1,2]. Despite substantial efforts in understanding the pathophysiology of sep

• With regard to the clinical implications of

  2019-07-08

  

  With regard to the clinical implications of this aspect, an important recent study including data on NAFLD patients reported that hepatic expression of VDR was in fact up-regulated in fatty livers compared to non-steatotic controls [69]. Noteworthy, this up-regulation of VDR was more pronounced in p

• The expressions of IL TNF and IL major

  2019-07-08

  

  The expressions of IL6, TNFα, and IL1β, major pro-inflammatory cytokines secreted during tissue damage [40], are decreased in the kidney of AM095 treated mice compared with STZ-vehicle group. However, the GSK1838705A of the inducer of microphage infiltration, MCP1, involved in early stage of inflam

• br Competing interests br Transparency document br Authors

  2019-07-06

  

  Competing interests Transparency document Authors' contributions Acknowledgments This work was supported by the Spanish Ministry of Economy and Business through the grant Plan Estatal SAF2017-83372-R (FEDER funds/UE) and MDM-2014-0370 through the “María de Maeztu” Programme for Units of

• br Conclusions Drosophila melanogaster has increased

  2019-07-06

  

  Conclusions Drosophila melanogaster has increased our understanding of the molecular bases of cardiac aging over recent decades. During which, the tools available for investigating the gene 186689-07-6 patterns and physiological changes involved, have advanced considerably. In humans, cardiac a

• In addition to the genetic mutations of

  2019-07-05

  

  In addition to the genetic mutations of α-synuclein and LRRK2, an increasing body of evidence suggests that posttranslational modifications (PTMs) are also critically involved in PD pathogenesis [4,5] (Fig. 1). While PTMs serve to facilitate the normal functions of α-synuclein and LRRK2 in the healt

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