• br J Biermann et al Genomics xxx

  2019-09-23

  

  J. Biermann, et al. Genomics xxx (xxxx) xxx–xxx A Stable genome Stable genome Unstable genome B Genome stability Stab Unstab C Dendrogram of gene BYL-719 data (n = 136)  E Fig. 1. Stratification of copy number and gene expression data by genome stability. (A) F

• br Introduction br Colorectal cancer

  2019-09-23

  

  1. Introduction Colorectal cancer (CRC) represents one of the most common ma-lignant tumors of digestive system worldwide, posing serious threats to human health (Schwingshackl et al., 2018). In China, CRC is the third most common cancer and the fifth most common causes of cancer death (Chen et

• br Unfortunately we were unable

  2019-09-16

  

  Unfortunately, we were unable to compare the performance of mPS with that of other representative tools including MammaPrint and Oncotype Dx 21–gene RS, given that these are commercial products and the formulas for their calculation have not been disclosed. However, we demonstrated the superiority

• In the antivascular endothelial growth

  2019-09-02

  

  In 2009 the antivascular endothelial growth factor (anti-VEGF) antibody (Ab) bevacizumab was approved as the first angiogenesis inhibitor (AI) for the treatment of non-squamous NSCLC. The second AI, ramucirumab (anti-VEGFR2 Ab), was approved in 2016 [7], [8]. In 2012 the first anaplastic lymphoma ki

• At present we do not

  2019-08-26

  

  At present, we do not suggest, that baseline STM should be used as a priori predictive biomarkers to guide therapy decisions. Current treatment guidelines depict clear indications for all available therapeutic options, so there is no clinical need for another baseline biomarker now. Future research

• br Determining cancer specific mortality and

  2019-08-26

  

  Determining cancer-specific mortality and survival in cancer registry data In cancer research, defining a valid outcome parameter as an indicator of clinical relevance has its challenges. Overall survival (or its related outcome measure, all-cause mortality) is generally considered the gold stand

• However some limitations should be acknowledged First only m

  2019-08-26

  

  However, some limitations should be acknowledged. First, only missense variants with MAF ≥ 0.05 were inspected in this study. Other polymorphisms within PTP genes including copy number variant and rare variants should also be investigated in future researches. Second, for the scope of designed probe

• Differences for the age group estimates are slightly larger

  2019-08-16

  

  Differences for the age-group estimates are slightly larger (Table 2A, Table 2B), however most of them are lower or close to 1 percentage point. For females, the median and mean value for absolute differences with the AIC model are equal to 0.083 and 0.229 percentage points respectively. Differences

• br Discussion Genetic variants in receptors

  2019-08-16

  

  Discussion Genetic variants in receptors for viral entry and/or oncogenesis have been documented to have functional consequences for pathogenicity. The genetic factors underlying susceptibility to KSHV infection and KS development are not fully understood. We therefore set out to identify sequenc

• In this context it is noteworthy that a Dutch study

  2019-08-11

  

  In this context it is noteworthy that a Dutch study [34] found that incidence under-estimation mainly concerned not pathologically confirmed and elderly PC cases, whose exclusion results in survival over-estimation. Thus, although we found that survival was poor, it might even be worse for these can

• br Materials and methods br Results br Discussion

  2019-07-30

  

  Materials and methods Results Discussion Pulmonary fibrosis could be caused by >200 factors, including autoimmune diseases, environmental and occupational exposure [30]. Particularly, silica serves as a serious risk factor in respiratory occupational diseases. To be specific, inhalation of

• The mitochondrial haplotype constitutes the genetic backgrou

  2019-07-30

  

  The mitochondrial haplotype constitutes the genetic background for host cells invaded by HBV. A comprehensive study on peripheral blood, tumor and/or adjacent non-tumor tissue from 49 HBV-HCC patients and 38 normal people revealed that people with mtDNA haplogroup M may have increased likelihood of

• Many receptor tyrosine kinases are expressed in activated HS

  2019-07-30

  

  Many receptor tyrosine kinases are expressed in activated HSCs and are associated with the development of liver fibrosis. These include platelet-derived growth factor receptor (PDGFR) [10], vascular endothelial growth factor receptor (VEGFR) [11], and epidermal growth factor receptor (EGFR) [12]. On

• br Materials and methods br Results

  2019-07-24

  

  Materials and methods Results Discussion In this study, we show that adaptive modifications of Ca2+ cycling through the hypertrophic response to chronic high blood pressure overload play a critical role during early development of MitoPY1 failure with nearly-normal ejection fraction (HFpEF

• br Materials and methods br

  2019-07-24

  

  Materials and methods Results Discussion Here, we described a mouse model in which paternal exposure to hyperglycemia leads to metabolic derangement and accumulation of fatty Etoposide in the adult offspring liver. Deregulation of genes related to hepatic lipid metabolism can be explained,

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