• All chemicals were purchased from

  2022-04-26

  

  All chemicals were purchased from Aladdin Chemical Co. All reac-tions were carried out under anhydrous conditions. Chromatography was performed on HPTLC silica gel 60 F254. HNMR spectra were re-corded on a Bruker AVANCE 300 MHz spectrometer, and CNMR spectra were recorded on Bruker AVANCE 400 MHz sp

• br Introduction br Cancer ranks as the leading cause of

  2022-04-22

  

  1. Introduction Cancer ranks as the leading cause of mortality in Japan. In 2017, around 30% of deaths have been attributed to cancer, making it a major health problem [1]. Approximately 90% of deaths are caused by cancer invasion and metastasis. During cancer progression, cancer Jasplakinolide

• Concanamycin A br Conflict of interest br None br Authors

  2022-04-22

  

  Conflict of interest None. Authors contribution AT (Corresponding author): conceived Concanamycin A and research ob-jectives, designed and performed experiments, gathered and analyzed data, drafted and critically revised the manuscript, and approved the final version. KKM (Contributor):

• br Lipid modified cationic peptides induce ROS

  2022-04-21

  

  3.4. Lipid-modified cationic peptides induce ROS mPTP induction and mitochondrial depolarization typically involve increased cellular levels of ROS, triggering complex signaling cascades that lead to cell death [1]. To test whether this was happening during the treatment of EMT6/AR-1 cells with

• br Cardiovascular disease particularly previous

  2022-04-21

  

  Cardiovascular disease (particularly previous myocardial infarction and valvular disease) greatly increases the risk for toxicities, particularly in patients receiving anthracycline-based chemotherapies [16–18]. The relation of risk factors to side effects from the novel therapies (molecu-larly ta

• br Previous to the inclusion of the HPV vaccine

  2022-04-16

  

  Previous to the inclusion of the HPV vaccine into the NIP in 2016, a survey on the knowledge and acceptability of HPV infection and vac-cination was performed among 140 mothers of children aged 9–14. Sixty-six mothers (47.0%) were aware of HPV infection, 67 (48.0%) had knowledge about HPV vaccinat

• br To examine the potential of proteotyping

  2022-04-15

  

  To examine the potential of proteotyping for breast cancer classification, we next constructed a decision tree to classify the 96 tumors into the five conventional subtypes based on their proteotypes. We started by selecting the most differentially abundant proteins (log2FC > 1.5; FDR-adj. p Fig

• br Table reports the LE and YLL

  2021-03-10

  

  Table 1 reports the LE and YLL for all cancer types combined for females, males, and both sexes by age at diagnosis and at specific time points after diagnosis (0, 1, 5, 10, and 15 years). Table 1. Life expectancy (LE) and years of life lost (YLL) of all cancer patients with respect to the age

• br Conclusion We observed an inverse

  2021-03-03

  

  Conclusion: We observed an inverse association between BMI and HNC risk, which is consistent with previous studies in other geographic regions. Being underweight at age 20 was also associated with a higher risk of HNC, suggesting that reverse causality was not the main source of the association.

• br and micelles Conjugation of curcumin to a

  2021-03-03

  

  [19] and micelles [20–22]. Conjugation of curcumin to a hydrophilic polymer is another way of tackling this problem. Polymer conjugates have an advantageous drug-to-excipient ratio compared to other, mentioned above systems, what reduces their potential to induce un-desired side effects. Additional

• br We did find a negative correlation between the

  2021-03-02

  

  We did find a negative correlation between the change in Ki-67 index and the change in ADC value as a result of NAC. This is consistent with the fact that the primary target of NAC is Ki-67-positive cells. As these RNA dye are destroyed, ARTICLE IN PRESS Figure 2. Scatterplots show the rela

• br Fig Pap smear segmentation

  2020-08-30

  

  Fig. 3. Pap smear segmentation to achieve pixel level classification.  and 200 from Dataset 2) was defined by Equation (2). Ni where Ni, Ci, Bi and Di are the number of pixels from the nucleus, cy-toplasm, background and debris of image i as shown in Fig. 4. Each pixel extracted from t

• br Supplementary materials br References br Lamont KR Tindal

  2020-08-30

  

  Supplementary materials References [2] Lamont KR, Tindall DJ. Minireview: alternative activation pathways for the androgen receptor in prostate cancer. Mol Endocrinol 2011;25:897–907. [3] Azad AA, Eigl BJ, Murray RN, Kollmannsberger C, Chi KN. Effi-cacy of enzalutamide following abiratero

• br Acknowledgements br This work

  2020-08-30

  

  Acknowledgements This work was supported by the Natural Science Foundation of Shandong Province (ZR2016HB05 and ZR2016HB45), the open project of Shandong Collaborative Innovation Center for Antibody Drugs (CIC-AD1827), the Postdoctoral Science Foundation of China (2018M632607), and the National

• br Lipid modified cationic peptides induce ROS

  2020-08-30

  

  3.4. Lipid-modified cationic peptides induce ROS mPTP induction and mitochondrial depolarization typically involve increased cellular levels of ROS, triggering complex signaling cascades that lead to cell death [1]. To test whether this was happening during the treatment of EMT6/AR-1 cells with

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