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  • br Conclusions br Metastatic lung cancer is

    2020-03-17


    7. Conclusions
    Metastatic lung cancer is a condition with poor prognosis in regards to its high morbidity and mortality. In this study, we aimed to analyze these various management modalities specifically for patients with metastatic lung cancer affecting the spine. Our sys-tematic review on the outcomes of 1925 patients elucidated a sta-tistically and clinically significant survival advantage with non-operative treatment approaches compared with surgical manage-ment. However, we did not find there to be statistically significant differences between different subtypes of primary lung cancer nor between the number of vertebral levels involved per lesion. This analysis suggests that less aggressive approaches, such as chemotherapy, radiation, and radiofrequency ablation may be ben-eficial for patients suffering from symptomatic spinal metastases from lung cancer. More aggressive surgical treatments may be bet-ter reserved only for those with life expectancy greater than 6 months, strong candidates for surgery, and pathologic fracture or MESCC presenting with neurologic deficits. Future randomized controlled trials are warranted to control for various patient pre-sentations in order to determine the treatment algorithm that maximizes survival of metastatic lung cancer.
    Competing interests
    The authors declare that they have no competing interests. No financial support or grants are associated with this submission.
    Appendix A. Supplementary data
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