• br natural compounds with low cytotoxicity in normal cells

  2022-06-21

  

   natural compounds with low cytotoxicity in normal cells are believed to be promising candidates for effectively overcoming various cancer species. TRAIL is known to promote apoptosis in cancer cells by binding to two death receptors, DR4 and DR5, which are mainly expressed on the surface of c

• br Materials and methods br Ethics

  2022-05-30

  

  Materials and methods Ethics statement The study was approved by the Ethics Committee for clinical research and complies with the tenets of the declaration of Hel-sinki and the Institutional Review Board of the participating cen-ters. Written informed consent for molecular genetic studies wa

• br Laser Capture Microdissection and miR

  2022-05-30

  

  Laser-Capture Microdissection and miR-182 Quantification by RT-qPCR LCM of benign prostate epithelium from frozen prostatectomy tissue and RNA isolation was performed previously.27 Briefly, cDNA was synthesized from 60 ng of LCM-collected  RNA with Universal RT miRNA reagents (Exiqon). qPC

• br Statistical Analyses br The primary aim of the

  2022-05-30

  

  Statistical Analyses The primary aim of the present study was to determine the association of methylation in CHFR, WRN, and SULF2, as well as CIMP status, with time to progression (TTP) of irinotecan-based systemic chemotherapy in patients with metastatic CRC. In addition to TTP, OS and respons

• br Introduction br Conventional chemotherapeutics su er from a

  2022-05-23

  

  1. Introduction Conventional chemotherapeutics suffer from a narrow therapeutic window due to their poor specificity towards tumor/healthy cells, leading to the so called “off-target” side effects (Zhou and Rossi, 2017). There is a need of developing targeted delivery systems to improve drug selec

• br side effects After internalization

  2022-05-23

  

   side effects. 3) After internalization of Apt-HSA/CCM NP to tumor cells, as it was observed in release studies, the release of drug has increased in pH 5 and medium containing GSH 10 mM. 4. Conclusion A new apt-targeted HSA NPs loaded with CCM for active targeting of HER2 overexpressing b

• br The e ects of HELT fraction emulsions on immune

  2022-05-23

  

  3.5. The effects of HELT fraction emulsions on immune function To assess the effects of F18 emulsions at different concentrations on immune function, we analyzed the SI value, NK cells and B cells. HD-E and MD-E promoted the proliferation of spleen cells as shown in Fig. 7. Moreover, the proportio

• br caption on next page br Fig aPKC

  2022-05-23

  

  (caption on next page) Fig. 3. aPKCι competes with Nrf2 for Keap1 binding through the DLL motif. (A) The protein levels of aPKCι and Nrf2 were determined by western blotting in negative control or aPKCι knockdown NOZ ATPγS with or without MG132 treatments (20 μM for 6 h). (B) The ubiquitinated

• Banerjee S Kaye SB New strategies in the treatment

  2022-05-22

  

  [24] Banerjee S, Kaye SB. New strategies in the treatment of ovarian cancer: cur-rent clinical perspectives and future potential. Clin Cancer Res 2013;19: 961e8. [30] Schmidt L, Duh F-M, Chen F, Kishida T, Glenn G, Choyke P, et al. Germline and somatic mutations in the tyrosine kinase domain of t

• br Our study on program cell death revealed that kusukokinin

  2022-05-22

  

  Our study on program cell death revealed that ( ± )-kusukokinin and its derivative, ( ± )-bursehernin, induced apoptosis through multi-caspase activity including caspase-1, -3, -4, -5, -6, -7, -8, and -9. Previous report showed that (-)-kusunokinin induced cleaved caspase-7 and -8 [14]. Similarly,

• br Cancer cell separation using Ab MNP Si in

  2022-05-22

  

  2.7. Cancer cell separation using Ab/MNP-Si in a mixture of fresh human whole blood To analyze the ability of Ab/MNP-Si to isolate HER2+ cells, SK-BR-3 GSK126 were stained with carboxyfluorescein succinimidyl ester (CFSE) as a live cell-staining fluorescent dye (which changes the color of the

• br All animal experiments were performed in

  2022-05-20

  

  All animal experiments were performed in accordance with the NIH guidelines on laboratory animal welfare and approved by the Institutional Animal Care and Use Committee of the National Taiwan University College of Medicine (IACUC number: 20110303). Data are expressed as mean values ± standard e

• br d QUANTIFICATION AND STATISTICAL ANALYSIS B Data preprocessing and

  2022-05-18

  

  d QUANTIFICATION AND STATISTICAL ANALYSIS B Data preprocessing and BP-R2 analysis B Hierarchical clustering B t-SNE analysis B Functional enrichment and association analysis using STRING database B Shortest signed directed path analysis using OmniPath B Shape-based clustering B Selecti

• In the present study we targeted the design of a

  2022-05-17

  

  In the present study, we targeted the design of a novel probe for the detection of HER2 biomarker. Amplification or over-expression of this oncogene plays an important role in the development and progression of certain aggressive types of breast cancer. In recent years the HER2 protein has become an

• br biometrics solving image video restoration problems using combination

  2022-05-15

  

  biometrics, solving image/video restoration problems using combination of classifiers using genetic programming, optimization of shaping functions in digital watermarking and image fusion.  Dr. Ikram Ud Din received his Ph.D. degree in Com-puter Science from the School of Computing, Universit

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