• br Conclusion We observed an inverse

  2021-03-03

  

  Conclusion: We observed an inverse association between BMI and HNC risk, which is consistent with previous studies in other geographic regions. Being underweight at age 20 was also associated with a higher risk of HNC, suggesting that reverse causality was not the main source of the association.

• br and micelles Conjugation of curcumin to a

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  [19] and micelles [20–22]. Conjugation of curcumin to a hydrophilic polymer is another way of tackling this problem. Polymer conjugates have an advantageous drug-to-excipient ratio compared to other, mentioned above systems, what reduces their potential to induce un-desired side effects. Additional

• br We did find a negative correlation between the

  2021-03-02

  

  We did find a negative correlation between the change in Ki-67 index and the change in ADC value as a result of NAC. This is consistent with the fact that the primary target of NAC is Ki-67-positive cells. As these RNA dye are destroyed, ARTICLE IN PRESS Figure 2. Scatterplots show the rela

• br Fig Pap smear segmentation

  2020-08-30

  

  Fig. 3. Pap smear segmentation to achieve pixel level classification.  and 200 from Dataset 2) was defined by Equation (2). Ni where Ni, Ci, Bi and Di are the number of pixels from the nucleus, cy-toplasm, background and debris of image i as shown in Fig. 4. Each pixel extracted from t

• br Supplementary materials br References br Lamont KR Tindal

  2020-08-30

  

  Supplementary materials References [2] Lamont KR, Tindall DJ. Minireview: alternative activation pathways for the androgen receptor in prostate cancer. Mol Endocrinol 2011;25:897–907. [3] Azad AA, Eigl BJ, Murray RN, Kollmannsberger C, Chi KN. Effi-cacy of enzalutamide following abiratero

• br Acknowledgements br This work

  2020-08-30

  

  Acknowledgements This work was supported by the Natural Science Foundation of Shandong Province (ZR2016HB05 and ZR2016HB45), the open project of Shandong Collaborative Innovation Center for Antibody Drugs (CIC-AD1827), the Postdoctoral Science Foundation of China (2018M632607), and the National

• br Lipid modified cationic peptides induce ROS

  2020-08-30

  

  3.4. Lipid-modified cationic peptides induce ROS mPTP induction and mitochondrial depolarization typically involve increased cellular levels of ROS, triggering complex signaling cascades that lead to cell death [1]. To test whether this was happening during the treatment of EMT6/AR-1 cells with

• br The exploration of socioeconomic and demographic fac tors

  2020-08-28

  

  The exploration of socioeconomic and demographic fac-tors focused on 104 patients in the external validation set. A total of 62 (60%) had next of kin staying at their address. There was no significant difference in mean length of stay when the group that stayed less than 15 days was tested (test s

• PF 06700841 br biodegradation and their less hydrophobic cha

  2020-08-28

  

  biodegradation and their less hydrophobic character. Our work also demonstrates the potential of targeting non-canonical targets with non-viral combination nanoparticles. Our combination approach may also be able to be extended to polymeric nanoparticles that contain DNA [45] and other RNAs in add

• br Cell culture and reagents

  2020-08-28

  

  2.2. Cell culture and reagents Human gastric adenocarcinoma cell lines, AGS (ATCC, VA, USA) and MGC-803 (CBTCCCAS, Shanghai, China), and human stomach fibroblat line Hs738 (ATCC, VA, USA) were cultured in the complete DMEM (ATCC, VA, USA) with 10% fetal calf serum. Cisplatin and human IL-8 w

• br A br Sham br BCF br RCF

  2020-08-28

  

  A Sham BCF RCF H-Thymidine D Sham 231BrM BCF ns 3H-ThymidineCPM (normalizedtoSham) 3H-ThymidineCPM(normalizedtoSham) Vehicle Ethosuximide (normalizedtoSham) %decrease -10 ns hrs/day s/day hr Sham SKBrM3 BCF ns 3H-Thymidine CPM Vehicl

• br MicroRNAs miRNAs are small non coding RNAs

  2020-08-28

  

  MicroRNAs (miRNAs) are small non-coding RNAs (21 to 23 nu-cleotides) that play an important role in cancer processes like cell proliferation, apoptosis and metastasis (Cho, 2007). miRNAs regulate the expression of target genes by binding to 3′ untranslated regions (UTRs) of its target mRNAs and in

• br used for preoperative localization before biopsy Similarl

  2020-08-18

  

  511 used for preoperative localization before biopsy. Similarly, the 512 distance between the centroid of the suspicious lesions on 513 456 suspicious lesions and to eliminate false positives using length of minor axis of the lesion, M1, measured in terms of 515 457 reduced annular

• br temperature of solutions with different concentrations in

  2020-08-18

  

  temperature of solutions with different concentrations increased to 26.7, 34.6, 41.8, and 49.7 °C, respectively. In order to evaluate the photothermal stability of BPNs-PDA-PEG-PEITC, the 100 μg/mL solu-tion was irradiated with 808 nm NIR laser for 5 min. After turning off the NIR laser, the solut

• br Finally regarding potential confounders

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  Finally, regarding potential confounders, several studies have shown that young women are more likely than older women to have never screened (Catarino et al., 2016; Were et al., 2011); with the lowest screening rates reported by women aged 20–29 years (42–51%), re-lative to those aged 45–54 years

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